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Bone marrow transplant with a non sibling matched donor requires more intensive conditioning with increased treatment related toxicity. The study treatment plan proposes the use of a reduced toxicity myeloablative conditioning regimen to increase the engraftment potential without serious complication.
Seoul National University Hospital, Seoul, Korea
This is a trial of bone marrow transplantation for patients with the diagnosis of a genetic disease of blood cells that do not have an HLA-matched sibling donor. The study treatment plan uses a new transplant treatment regimen that aims to try to decrease the acute toxicities and complications associated with the standard treatment plans and to improve outcome
Children's Hospital Los Angeles
- Hisham Abdel-Azim, MD. 323-361-8556, E Mail: firstname.lastname@example.org
Determine the safety of a non-ablative conditioning and post-transplantation immunosuppression regimen who undergo HLA-matched related or unrelated bone marrow transplantation to induce mixed hematopoietic chimerism
Fred Hutchinson Cancer Research Center, Seattle, Washington
- Lauri Burroughs, MD, E Mail: email@example.com
Donor T lymphocytes that have been treated with the Epstein-Barr virus may help the body build an effective immune response to kill cancer cells. This trial studies the side effects and the best way to give T Lymphocytes in treating patients undergoing a bone marrow transplant.
Baylor College of Medicine, Texas Children's Cancer Center and Methodist Hospital, Houston, TX
- Clinical Trials Office 713-798-1297 or Catherine Perera 832-824-4594
To determine the feasibility of attaining acceptable rates of donor cell engraftment (>25% donor chimerism at 180 days) following reduced intensity conditioning (RIC) regimens in pediatric patients.
Duke University, Durham, NC.
This phase II trial is studying how well giving treosulfan together with fludarabine phosphate followed by donor stem cell transplant works in treating patients with noncancerous inherited disorders.