Research

    Grants Awarded

    The Wiskott-Aldrich Foundation launched it's Research Program in 2011.  We received a number of excellent applications from the brightest physicians and scientists from around the world.  By investing in promising people and projects we continue to make strides in unraveling the mysteries of WAS, explore avenues for improved cures and find ways to improve the quality of life for those who are impacted by WAS.  We thank our generous donors who have made our research program possible.

    2012 Designated Grants

    One Year Grant
    Dr. Gerben Bouma, PhD.
    University College, London
    Dr. Luigi Notarangelo, M.D.
    Children's Hospital, Boston
    Dr. Adrian Thrasher, M.D., PhD, FRCP, MRCPH, FMedSci
    UCL Institute of Child Health

    "Dissecting the contribution of individual B and T cell subsets to the development of autoimmunity in Wiskott-Aldrich Syndrome."  
    Autoimmune conditions such as arthritis, hemolytic anemia, ITP, nephritis are seen in 40-70% of patients with WAS and are difficult to treat.  This international collaboration project is aimed at understanding the biologics of autoimmunity in patients with WAS and will hopefully lead to targeted pharmaceutical and biologic therapies in the treatment of these conditions.

    Funding for this project was provided in part by a generous grant from the WAS Foundation.

    Two Year Grant
    Dr. David Rawlings, M.D.
    Seattle Childrens' Research Institute
    Dr. Troy Torgerson, M.D.
    Seattle Children's Research Institute

    "Monitoring of B Cell Tolerance in Wiskott-Aldrich Syndrome patients following stem cell transplantation."
    Autoimmunity is frequently seen in post-transplant patients with mixed chimerism (patient has cells from the donor and his own cells after a transplant).  This project studies the cause for autoimmunity in these patients and hopefully help design therapeutic interventions to prevent this complication.  This project is being conducted as a part of a larger PIDTC study on WAS.

    This project was funded by the Wiskott-Aldrich Foundation.


     

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